![]() ![]() In cases of kidney damage, however, additional treatment may be required. Oftentimes, hyaline casts are not always considered to be an unusual finding, and thus may not require treatment at all. Microscopy stains or dim lighting may also be used to help identify particles. Phase contrast microscopy may be used to enhance the contrast in order to better visualize the particles. Hyaline casts can be identified as clear, tiny tubule-shaped particles. Small drop of urine sediment is examined under a microscope. Hyaline casts can be diagnosed through urinalysis.Ĭentrifugation of a urine sample to separate urine sediment (e.g., casts, cells, pathogenic microorganisms) from fluid. In addition, hyaline casts may appear alone or in association with other types of casts in certain pathological conditions, including acute kidney injury. Increased precipitation of Tamm-Horsfall protein can be caused by a variety of factors:Ĭonsequently, it’s possible to detect a greater amount of hyaline casts after strenuous exercise, during treatment with certain types of diuretic medications, or in individuals with severe vomiting or fever (indicative of dehydration). Hyaline casts are composed of aggregated Tamm-Horsfall protein in the tubular lumen of the kidney. Join millions of students and clinicians who learn by Osmosis! Start Your Free Trial What causes hyaline casts? Examples of non-cellular casts include hyaline casts, granular casts, fatty casts, and waxy casts, among others. Examples of cellular casts include renal tubular epithelial casts, red blood cell (RBC) casts, and white blood cell (WBC) casts. Once the urinary casts have developed, they can dislodge from the tubular lumen and travel through the urinary tract, before being excreted in the urine.ĭepending on the composition, urinary casts can be categorized into cellular casts and non-cellular casts. cells, bile, hemoglobin, albumin, immunoglobulins). Aggregation of Tamm–Horsfall protein into a protein matrix can then attract the adhesion of other tubular particles (e.g. It results from the precipitation of Tamm–Horsfall protein (also known as uromodulin) which is secreted by the epithelial tubule cells. ![]() Each nephron is composed of a glomerulus (a ball-shaped network of blood vessels involved in the formation of urine) and kidney tubules (a series of tubules that reabsorb and modify urine composition according to the body’s necessities).Cast formation takes place in the final portion of the kidney tubules, which consists of the distal convoluted tubules and collecting ducts. They’re composed of millions of filtering units called nephrons. The kidneys are two bean-shaped organs located in the abdomen, at either side of the lower spine. Urinary casts serve as clinical indicators of kidney condition and can be assessed to determine the functioning of the kidneys. Urinary casts are microscopic clusters of urinary particles, such as cells, fat bodies, or microorganisms, wrapped in a protein matrix and found in the urine. ![]() Hyaline casts are the simplest and most common type of urinary cast. Illustrator : Jillian Dunbar What are hyaline casts? Back Hyaline Casts What Are They, Causes, Diagnosis, Treatment, and MoreĮditor s : Ahaana Singh, Lisa Miklush, PhD, RN, CNS ![]()
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